Diabetes mellitus is associated with disturbances of cognitive functioning. Diabetes impaired spatial learning and memory of rats. The aim of this study was to examine cognitive functioning in diabetic rats. Diosmin has been reported to exhibit anti-hyperglycemic, antioxidant effects. Therefore we tested its efficacy against memory dysfunction in streptozotocin-induced diabetic rats. Diosmin was administered to streptozotocin-induced diabetic rats at different doses ( 50, 100 mg/kg b.w)for four weeks . Thirty days after diabetes induction rats showed a severe deficit in learning and memory associated with increased lipid peroxidation,nitric oxide level decreased reduced glutathione, and elevated ChE activity in hippocal region. Different parameter such as Morris water maze , object recognition test were performed . Lipid peroxidation and glutathione levels as parameters of oxidative stress was evaluated.To rule out possibility for locomotor activity open field test was conducted. In conclusion diosmin showed marked improvement in memory of diabetic rats ,prevent changes in oxidative stress and cholinesterase activity. . Furthermore, protection against body weight loss of diabetic animals was also observed. These concluded that diosmin has potential in treatment of diabetic memory dysfunction.
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